![]() All relevant data are within the manuscript. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The authors confirm that all data underlying the findings are fully available without restriction. ![]() Received: JAccepted: OctoPublished: December 1, 2014Ĭopyright: © 2014 Bogachev et al. ![]() We suggest that this functional form is a footprint of the heterogeneous DNA structure, where the first -exponential reflects the universal helical pitch that appears both in pro- and eukaryotic DNA, while the second -exponential is a specific marker of the large-scale eukaryotic DNA organization.Ĭitation: Bogachev MI, Kayumov AR, Bunde A (2014) Universal Internucleotide Statistics in Full Genomes: A Footprint of the DNA Structure and Packaging? PLoS ONE 9(12):Įditor: Enrique Hernandez-Lemus, National Institute of Genomic Medicine, Mexico While in prokaryotes a single -exponential function makes the best fit, in eukaryotes the PDF contains additionally a second -exponential, which in the human genome makes a perfect approximation over nearly 10 decades. We find that in all considered organisms the internucleotide interval distributions exhibit the same -exponential form. Sapiens aiming to reveal the manifestation of the universal DNA architecture. Here we investigate the distributions of the internucleotide intervals and their persistence properties in complete genomes of various organisms from Archaea and Bacteria to H. Uncovering the fundamental laws that govern the complex DNA structural organization remains challenging and is largely based upon reconstructions from the primary nucleotide sequences.
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